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Related Experiment Video

Updated: May 19, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

Complete hydatidiform mole coexisting with a live fetus.

M A Unsal¹, S Guven

¹Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. mesutunsal@gmail.com

Clinical and Experimental Obstetrics & Gynecology

|August 22, 2012

Summary

Hydatidiform mole co-existing with a live fetus is rare and poses maternal and fetal risks. Careful monitoring may allow continued pregnancy, but intrauterine fetal death remains a possibility.

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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

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Area of Science:

Obstetrics and Gynecology
Reproductive Medicine
Maternal-Fetal Medicine

Background:

Co-existence of hydatidiform mole and live fetus presents diagnostic and management challenges.
Associated maternal risks include preeclampsia, hyperthyroidism, and malignancy.
Fetal risks involve spontaneous abortion and neonatal thyrotoxicosis.

Observation:

A 27-year-old woman presented with a hydatidiform mole and live fetus.
Ultrasound confirmed a viable fetus and a co-existing hydatidiform mole.
Genetic amniocentesis revealed a normal fetal karyotype.

Findings:

Despite a normal fetal karyotype and absence of severe maternal pathology, intrauterine fetal death occurred at 20 weeks.
The patient had a two-year uneventful follow-up.

Implications:

Waiting until fetal viability may be considered in select cases with normal karyotype and stable maternal health.
Pregnancy continuation carries a risk of prenatal complications, including intrauterine fetal death.
This case highlights the complex management decisions in rare molar pregnancies with viable fetuses.