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Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
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Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Dapsone induced eosinophilic pneumonia.

T Adar1, O Tayer-Shifman, M Mizrahi

  • 1Internal Medicine A Department of Medicine, Hadassah-Hebrew University Medical Center Jerusalem, Israel. adartom@szmc.org.il

European Annals of Allergy and Clinical Immunology
|August 22, 2012
PubMed
Summary
This summary is machine-generated.

Dapsone, an antibiotic for leprosy, can cause eosinophilic pneumonia. This case report details a leprosy patient diagnosed with this condition, confirmed by diagnostic tests and treatment response.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Infectious Diseases

Background:

  • Eosinophilic lung diseases (ELD) encompass diverse clinical conditions with varied causes.
  • Drug-induced ELD is a recognized, though less common, etiology.
  • Dapsone, a sulfone antibiotic, is a known potential trigger for ELD.

Observation:

  • A patient with leprosy presented with new respiratory symptoms and pulmonary infiltrates.
  • Initial investigations suggested an eosinophilic pneumonia.

Findings:

  • The diagnosis of dapsone-induced eosinophilic pneumonia was established.
  • Diagnostic support included bronchoalveolar lavage and lung biopsy.
  • The patient showed a characteristic positive response to dapsone therapy cessation.

Implications:

  • This case highlights dapsone as a specific cause of eosinophilic pneumonia.
  • Confirms the diagnostic utility of bronchoalveolar lavage and biopsy in such cases.
  • Emphasizes the importance of considering drug-induced lung disease in patients on dapsone.