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Updated: May 19, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Enantioselective total synthesis of (-)-laurenditerpenol
Emmanuel N Pitsinos1, Nikolaos Athinaios, Veroniki P Vidali
1NCSR Demokritos, P.O. Box 60228, GR-153 10 Ag. Paraskevi, Athens, Greece. pitsinos@chem.demokritos.gr
Abstract:
A highly convergent total synthesis of (-)-laurenditerpenol has been accomplished through an organolithium to aldehyde nucleophilic addition. Preparation of the prerequisite key intermediates in optically pure form was based on an improved, short, and efficient synthesis of "wine lactone" from (S)-limonene and Corey's catalytic enantioselective Diels-Alder reaction of 2,5-dimethyl furan with diethyl fumarate.
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