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Related Concept Videos

Pneumothorax-II01:27

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...
Atelectasis II: Pathophysiology01:10

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...

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Related Experiment Video

Updated: May 19, 2026

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
08:46

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation

Published on: July 26, 2017

Mechanostructural adaptations preceding postpneumonectomy lung growth.

Barry C Gibney1, Jan P Houdek, Kenji Chamoto

  • 1Laboratory of Adaptive and Regenerative Biology, Brigham and Women's Hospital, Harvard, Medical School, Boston, Massachusetts, USA.

Experimental Lung Research
|August 22, 2012
PubMed
Summary

Compensatory lung growth after pneumonectomy involves significant cardiac lobe displacement and altered respiratory mechanics. These mechanical changes, particularly increased tissue damping and elastance, may signal the onset of lung regrowth.

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Related Experiment Videos

Last Updated: May 19, 2026

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
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Mouse Pneumonectomy Model of Compensatory Lung Growth
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Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Comparative Anatomy

Background:

  • Pneumonectomy triggers compensatory lung growth in many species.
  • While late effects are known, early anatomic and mechanical changes during murine compensatory lung growth remain unclear.

Purpose of the Study:

  • To investigate structural and mechanical adaptations during compensatory lung growth post-pneumonectomy in mice.
  • To correlate mechanical changes with the timing of compensatory growth.

Main Methods:

  • Mice underwent left pneumonectomy and were studied for 21 days.
  • Microcomputed tomography (microCT) assessed anatomic changes.
  • Respiratory system impedance (FlexiVent) measured lung mechanics.

Main Results:

  • Significant cardiac lobe displacement observed post-pneumonectomy.
  • Increased lung volumes with decreased distensibility and elevated quasi-static compliance and elastance.
  • On day 3, oscillatory mechanics revealed increased tissue damping and elastance, with unchanged hysteresivity.

Conclusions:

  • Mechanical changes following pneumonectomy, including increased tissue damping and elastance, occur early.
  • The timing of these mechanical alterations suggests they act as a signal for compensatory lung growth.