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Updated: May 19, 2026

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
Published on: July 3, 2020
The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?
Eric Farfour1, Frédéric Charlotte, Catherine Settegrana
1Laboratoire de parasitologie-mycologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
Background:
Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.
Methods:
The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.
Results:
A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.
Discussion And Conclusion:
These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
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