Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Introduction to the issue: Cellular therapies in rheumatology.

Best practice & research. Clinical rheumatology·2026
Same author

Predictive correlates of arthritis and joint damage in systemic lupus erythematosus: a multinational prospective cohort study.

Rheumatology (Oxford, England)·2026
Same author

CAR T-cell therapy "Living drugs" in systemic lupus erythematosus.

Best practice & research. Clinical rheumatology·2026
Same author

T-cell engagers in rheumatology.

Best practice & research. Clinical rheumatology·2026
Same author

Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: A Randomized, Phase 3 Study.

Arthritis & rheumatology (Hoboken, N.J.)·2025
Same journal

"People, not tasks" a critical perspective on the transformation of work in long-term care.

Social work in health care·2026
Same journal

Roles of social workers and community health extension workers in enhancing access to maternal and child health services: reflection on a Nigerian intervention.

Social work in health care·2026
Same journal

Navigating social support, mental well-being, and health-seeking behavior among African immigrant women in Türkiye: Implications for social work in health care.

Social work in health care·2026
Same journal

Trends in referrals to psychosocial services in a pediatric emergency department before and after the onset of the COVID-19 pandemic.

Social work in health care·2026
Same journal

Between duty and dignity navigating medical social work practice with unknown patients in India's government medical college and public healthcare system.

Social work in health care·2026
Same journal

'We are the gatekeepers': the role of health Social workers in safeguarding health equity during emergency discharge policies.

Social work in health care·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Systemic lupus erythematosus: an overview.

Anca Askanase1, Katrina Shum, Hal Mitnick

  • 1Department of Rheumatology, NYU School of Medicine, New York, New York 10016, USA. Anca.Askanase@nyumc.org

Social Work in Health Care
|August 22, 2012
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) is an autoimmune disease where the immune system attacks the body. This overview covers SLE epidemiology, diagnosis, manifestations, treatment, and patient impact.

More Related Videos

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Related Experiment Videos

Last Updated: May 19, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

  • Immunology
  • Rheumatology
  • Internal Medicine

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disorder of unknown cause.
  • The immune system mistakenly attacks healthy tissues and organs, including skin, joints, kidneys, heart, and brain.
  • SLE presents with a wide range of symptoms, from mild rashes to severe, life-threatening organ damage.

Purpose of the Study:

  • To provide a comprehensive medical overview of Systemic Lupus Erythematosus (SLE).
  • To discuss the epidemiology, diagnostic challenges, clinical manifestations, and treatment complexities of SLE.
  • To highlight the impact of SLE on patients' lives and review therapeutic progress over the past century.

Main Methods:

  • Literature review and synthesis of existing medical knowledge on SLE.
  • Analysis of epidemiological data, diagnostic criteria, and clinical presentations.
  • Examination of current and historical treatment strategies and their outcomes.

Main Results:

  • SLE affects multiple organ systems, with variable severity and presentation.
  • Diagnosis can be challenging due to the diverse and overlapping symptoms.
  • Treatment involves managing symptoms, preventing organ damage, and requires a multidisciplinary approach.

Conclusions:

  • Understanding SLE requires a holistic view of its epidemiology, diverse clinical spectrum, and treatment challenges.
  • Continued research is crucial for advancing SLE therapy and improving patient outcomes.
  • Effective SLE management necessitates addressing both the immunological basis and the profound impact on patients' lives.