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Related Experiment Video

Updated: May 19, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

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Published on: August 18, 2023

Systemic propolis stimulates new bone formation at the expanded suture: a histomorphometric study.

Burcu A Altan¹, Isa M Kara, Ruhi Nalcaci

¹Department of Orthodontics, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey. burcuk12@yahoo.com

The Angle Orthodontist

|August 22, 2012

Summary

Systemic propolis administration accelerated new bone formation in rats with expanded premaxillary sutures. This natural compound increased osteoblast and osteoclast activity, promoting faster healing.

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Last Updated: May 19, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

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Published on: August 18, 2023

The Establishment of Calvarial Suture-Bony Composite Defects in Rats: A Standardized Model for Suture-Regenerative Therapy Investigation

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomedical Science
Regenerative Medicine
Oral and Maxillofacial Surgery

Background:

The premaxillary suture is crucial for midfacial growth.
Expansion of this suture is a common orthodontic procedure.
Understanding factors that enhance bone regeneration is vital for successful outcomes.

Purpose of the Study:

To evaluate the effect of systemically administered propolis on the expanded premaxillary suture in a rat model.
To investigate propolis's influence on bone healing and cellular activity.

Main Methods:

Twenty-four rats were divided into three groups: expansion only, expansion plus propolis, and control.
A 5-day expansion period was followed by 12 days of retention.
Histomorphometric analysis assessed osteoclasts, osteoblasts, capillaries, inflammation, and new bone formation.

Main Results:

Propolis group showed significantly higher inflammatory cell intensity, osteoblast numbers, and new bone formation compared to controls.
Increased osteoclast numbers and new capillaries were also observed in the propolis group.
These findings suggest propolis enhances bone regenerative processes.

Conclusions:

Systemic propolis administration may accelerate new bone formation in expanded sutures.
Propolis demonstrates potential as an adjunct therapy to promote bone healing in craniofacial applications.
Further research could explore optimal dosages and clinical applications.