Related Experiment Videos
Candidal infection in oral lichen planus
D A Hatchuel1, E Peters, J Lemmer
1Department of Oral Pathology, University of the Witwatersrand, Johannesburg, South Africa.
Oral Surgery, Oral Medicine, and Oral Pathology
|August 1, 1990
Summary
Candidal infection is common in oral lichen planus (LP) and nonspecific lichenoid stomatitis (NSLS), but not associated with ulceration in LP. The study examined infection prevalence in these conditions.
Area of Science:
- Oral pathology
- Mycology
- Dermatology
Background:
- Oral lichen planus (LP) and nonspecific lichenoid stomatitis (NSLS) are inflammatory oral conditions.
- The role of candidal infection in these conditions, particularly concerning ulceration, requires further investigation.
Purpose of the Study:
- To determine the prevalence of candidal infection in oral lichen planus (LP) and nonspecific lichenoid stomatitis (NSLS).
- To assess the association between candidal infection and ulceration in LP and NSLS.
Main Methods:
- Histopathological reassessment of archived LP and NSLS cases.
- Periodic acid-Schiff staining to identify intraepithelial candidal pseudohyphae.
- Comparison with normal and hyperkeratotic mucosal controls.
Main Results:
- Candidal infection was found in 17.4% of ulcerated and 16.4% of nonulcerated LP cases.
- Infection prevalence was higher in NSLS (40.0% ulcerated, 16.7% nonulcerated).
- No significant association between candidal infection and ulceration was observed in LP.
Conclusions:
- Candidal infection occurs frequently in LP and NSLS.
- Ulceration does not appear to be a predisposing factor for candidal infection in LP.
- The increased prevalence in ulcerated NSLS warrants further study.