Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lipoproteins, elastases and atherogenesis].

W Hornebeck1

  • 1URA 1174, CNRS, Faculté de Médecine, Hôpital Henri-Mondor, Créteil, France.

Pathologie-Biologie
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Elastase-Like Enzyme of Platelets.

Thrombosis and haemostasis·2019
Same author

CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo.

The British journal of dermatology·2010
Same author

Inhibition of human neutrophil elastase by wheat ceramides.

International journal of cosmetic science·2009
Same author

Encapsulation of all-trans retinoic acid into wheat ceramides micro vesicles enhanced influence on collagenase and tissue inhibitor of metalloproteinase-1 production by human skin fibroblasts.

International journal of cosmetic science·2008
Same author

Elastokine-mediated up-regulation of MT1-MMP is triggered by nitric oxide in endothelial cells.

The international journal of biochemistry & cell biology·2008
Same author

Elastolysis induces collagenolysis in a gingival lamina propria model.

Journal of dental research·2006

Lipid deposition and elastic lamellae fragmentation drive atherosclerosis. Lipoprotein interactions with arterial cells influence elastase, a protease that can degrade lipoproteins, impacting their properties.

Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Cellular Biology

Context:

  • Atherogenesis involves lipid deposition and elastic lamellae fragmentation.
  • Lipoprotein interactions with arterial wall cells are crucial.
  • Elastase plays a role in arterial wall remodeling.

Purpose:

  • To explore the relationship between lipoproteins and elastase in atherogenesis.
  • To understand how arterial cells modulate elastase in response to lipoproteins.
  • To investigate the impact of elastase on lipoprotein structure and function.

Summary:

  • Lipoprotein interactions with mesenchymal and inflammatory arterial wall cells can alter elastase expression and secretion.
  • Elastase, a neutral protease, can degrade lipoprotein components.

Related Experiment Videos

  • This degradation modifies the physical and biological characteristics of lipoproteins.

    • Impact:

    • Provides insights into the molecular mechanisms of atherogenesis.
    • Highlights potential therapeutic targets related to lipoprotein modification and elastase activity.
    • Enhances understanding of the interplay between lipids, proteins, and cellular processes in vascular disease.