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Updated: May 19, 2026
Non-invasive 3D-Visualization with Sub-micron Resolution Using Synchrotron-X-ray-tomography
Published on: May 27, 2008
Phase-contrast microtomography with synchrotron radiation technology: a new noninvasive technique to analyze the
Yuzhi Jiang1, Yajun Tong, Tiqiao Xiao
1Shanghai Burn Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.
Background:
Since the three-dimensional (3-D) structure of dermal tissue has an important role in regulating cell behavior and directing the wound healing process, the characteristic of the 3-D structure of dermal tissue needs to be clarified.
Objective:
To explore the different 3-D structures between normal and scar dermal tissues.
Material And Methods:
Phase-contrast microtomography with synchrotron radiation technology was applied to detect the 3-D structure of dermal tissues.
Results:
The normal dermal tissue consists of elliptical structures formed by fiber bundles interwoven in a helical manner. A regular louver-like structure was observed on the fibers. In scar tissue, the fiber bundles were arrayed in parallel, the louver-like structures were disordered.
Conclusion:
The study demonstrates the mesoscopic difference between normal dermal tissue and scar tissue, suggests that the high level of interweaving capability of collagen is compromised/lost when dermal tissue is injured, and provides a basis for future studies.
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