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Published on: September 14, 2018
Fc engineering: design, expression, and functional characterization of antibody variants with improved effector
Stefanie Derer1, Christian Kellner, Sven Berger
1Division for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University, Kiel, Germany.
Monoclonal antibody therapy for cancer shows promise but has limitations. Fc engineering offers a way to improve antibody effector functions, creating "fit-for-purpose" antibodies to overcome these challenges.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Monoclonal antibodies are a cornerstone of modern cancer therapy.
- Limitations exist, including inefficient effector cell recruitment and complement-dependent cytotoxicity (CDC).
Purpose of the Study:
- To explore advancements in antibody engineering for improved cancer immunotherapy.
- To discuss how Fc engineering can enhance antibody effector functions.
Main Methods:
- Review of current antibody engineering technologies.
- Analysis of Fc engineering approaches to modulate effector functions like antibody-dependent cell-mediated cytotoxicity (ADCC) and CDC.
Main Results:
- Fc engineering allows tailoring of antibody effector functions.
- Development of "fit-for-purpose" antibodies and antibody derivatives is possible.
Conclusions:
- Fc engineering holds significant potential to enhance monoclonal antibody therapy for cancer.
- Novel antibody designs may overcome existing limitations in cancer treatment.
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