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Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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Published on: March 7, 2025

Thyroid function in fetuses with down syndrome.

Dominique Luton1, Elie Azria, Michel Polak

  • 1Department of Obstetrics and Gynaecology at Hôpital Beaujon, Paris, France.

Hormone Research in Paediatrics
|August 22, 2012
PubMed
Summary
This summary is machine-generated.

Down syndrome fetuses may experience fetal hypothyroidism, indicated by elevated thyroid-stimulating hormone (TSH) and low free thyroxine (FT4) levels. This suggests delayed thyroid maturation in fetuses with Down syndrome.

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Area of Science:

  • Endocrinology
  • Genetics
  • Fetal Medicine

Background:

  • Elevated thyroid-stimulating hormone (TSH) is common in Down syndrome patients postnatally.
  • Neonatal screening often misses early signs of thyroid dysfunction in these infants.

Purpose of the Study:

  • To investigate the hypothesis that Down syndrome is associated with fetal hypothyroidism.
  • To determine if fetuses with Down syndrome exhibit evidence of hypothyroidism.

Main Methods:

  • Prospective observational study of 13 prenatally diagnosed Down syndrome fetuses.
  • Measurement of fetal blood TSH and free thyroxine (FT4) levels.
  • Comparison with fetal sonography and histopathology findings.

Main Results:

  • Six of 13 fetuses showed TSH levels above the 95th percentile with concurrently low FT4.
  • No sonographic evidence of goiter was observed.
  • Thyroid glands appeared normal grossly but showed histological signs of delayed maturation.

Conclusions:

  • The findings suggest fetal hypothyroidism in a subset of Down syndrome fetuses.
  • Absence of goiter in hyperthyrotropinemic fetuses indicates potential mild TSH responsiveness decrease.