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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Skin disease in dermatomyositis.

Lisa C Zaba1, David F Fiorentino

  • 1Department of Dermatology, Stanford University School of Medicine, California 94063, USA.

Current Opinion in Rheumatology
|August 22, 2012
PubMed
Summary

Dermatomyositis skin disease updates include new insights into pathogenesis and therapy. Quantitative tools now enable its use in clinical trials, aiding prognosis and diagnosis.

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Dermatomyositis is an idiopathic inflammatory myopathy characterized by distinct skin manifestations.
  • Understanding the skin's role in dermatomyositis is crucial for comprehensive patient management.

Purpose of the Study:

  • To review current knowledge on the pathogenesis, clinical features, and treatment of skin disease in dermatomyositis.
  • To highlight recent advancements in understanding interferon's role and developing quantitative measures for skin disease activity.
  • To emphasize the diagnostic and prognostic value of recognizing dermatomyositis skin disease heterogeneity.

Main Methods:

  • Literature review of recent studies on dermatomyositis pathogenesis, clinical manifestations, and therapy.
  • Analysis of new insights into interferon's role in skin disease.

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  • Evaluation of quantitative tools for measuring skin disease activity.
  • Assessment of the heterogeneity of skin disease in dermatomyositis.

    • Main Results:

    • Skin inflammation in dermatomyositis correlates with systemic and malignancy risks.
    • Pathogenic similarities may exist between muscle and skin inflammation.
    • Further prospective studies are needed for optimal management of skin manifestations, including calcinosis cutis.

    Conclusions:

    • Accurate classification of dermatomyositis skin disease can improve prediction of cancer, lung, and muscle involvement.
    • Studying skin may elucidate disease propagation mechanisms due to shared gene expression patterns with muscle.