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Co-morbidities of interstitial cystitis.
Gisela Chelimsky1, Elizabeth Heller, C A Tony Buffington
1Department of Pediatric Gastroenterology, Medical College of Wisconsin Milwaukee, WI, USA.
Frontiers in Neuroscience
|August 22, 2012
Summary
Patients with interstitial cystitis/painful bladder syndrome (IC/BPS) frequently experience co-occurring conditions like irritable bowel syndrome (IBS) and fibromyalgia (FM). These findings suggest IC/BPS may be linked to broader nervous system dysfunction.
Area of Science:
- Urology
- Gastroenterology
- Neurology
- Pain Medicine
Background:
- Interstitial cystitis/painful bladder syndrome (IC/BPS) is a chronic condition affecting the bladder.
- Systemic co-morbidities are frequently observed in patients with IC/BPS.
- Understanding these co-morbidities is crucial for comprehensive patient care.
Purpose of the Study:
- To estimate the prevalence of systemic dysfunction co-morbidities in patients with IC/BPS.
- To investigate associations between IC/BPS and conditions such as irritable bowel syndrome (IBS) and fibromyalgia (FM).
Main Methods:
- Two groups of IC/BPS patients were studied: physician-diagnosed and those meeting NIDDK criteria via questionnaire (ODYSA).
- Participants were compared to age- and socio-economic status-matched healthy controls.
- The ODYSA instrument assessed a wide range of symptoms, including those related to IBS, FM, and autonomic dysfunction.
Main Results:
- Co-morbid symptoms in IC/BPS groups included gastrointestinal issues (IBS, dyspepsia), sleep disturbances, chronic fatigue, generalized pain, migraines, and syncope.
- Patients with IC/BPS exhibited a higher burden of systemic complaints compared to controls.
Conclusions:
- IC/BPS patients frequently present with co-occurring central and autonomic nervous system disorders.
- Findings support links between IC/BPS and IBS, fibromyalgia symptoms, chronic pain, and migraines.
- High rates of syncope and functional dyspepsia warrant further investigation into IC/BPS as part of a diffuse disorder affecting multiple organ systems.
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