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A novel finding in MNGIE (mitochondrial neurogastrointestinal encephalomyopathy): hypergonadotropic hypogonadism

Ismail Hakki Kalkan1, Oykü Tayfur, Erkin Oztaş

  • 1Gastroenterology, Türkiye Yuksek Ihtιsas Hospιtal, Ankara, Turkey. drismailster@gmail.com

Hormones (Athens, Greece)
|August 22, 2012
PubMed
Abstract

No abstract available in PubMed .

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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...

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