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Updated: May 19, 2026

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform
Published on: November 9, 2017
PlGF: a multitasking cytokine with disease-restricted activity
Mieke Dewerchin1, Peter Carmeliet
1Laboratory of Angiogenesis and Neurovascular Link, VIB Vesalius Research Center, K.U. Leuven, Leuven, Belgium.
Placental growth factor (PlGF), unlike VEGF, plays crucial roles in diseases like ischemia and cancer. Research reveals its molecular mechanisms and therapeutic potential in blocking or delivering PlGF for various disorders.
Area of Science:
- Molecular biology
- Biochemistry
- Pathology
Background:
- Placental growth factor (PlGF) is part of the vascular endothelial growth factor (VEGF) family.
- Unlike VEGF, PlGF is not essential for normal development or health.
Purpose of the Study:
- To elucidate the molecular mechanisms of PlGF.
- To explore the therapeutic potential of modulating PlGF in various diseases.
Main Methods:
- Genetic gain-of-function and loss-of-function studies.
- Pharmacological interventions.
- Analysis of PlGF's roles in disease models.
Main Results:
- PlGF has diverse, nonredundant roles in conditions such as tissue ischemia, malignancy, and inflammation.
- Molecular mechanisms underlying PlGF's functions have been identified.
Conclusions:
- PlGF is a significant factor in multiple disease pathologies.
- Targeting PlGF (delivery or blockade) offers therapeutic strategies for various disorders.
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