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Angiotensin-converting enzyme in sarcoid uveitis.

R N Weinreb, J J O'Donnell, R Sandman

Investigative Ophthalmology & Visual Science

|December 1, 1979

Summary

Elevated serum angiotensin-converting enzyme (ACE) levels may indicate ocular sarcoidosis, even without systemic disease. This finding aids in diagnosing chronic granulomatous uveitis when other causes are unknown.

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Area of Science:

Ophthalmology
Immunology
Rheumatology

Background:

Ocular sarcoidosis diagnosis is often presumptive without systemic involvement.
Elevated serum angiotensin-converting enzyme (ACE) levels are linked to active systemic sarcoidosis.

Purpose of the Study:

To investigate the utility of serum ACE levels in diagnosing ocular sarcoidosis.
To determine if elevated ACE levels are present in patients with chronic granulomatous uveitis but no systemic sarcoidosis.

Main Methods:

Utilized a sensitive fluorimetric assay to measure serum ACE levels.
Analyzed ACE levels in patients with chronic granulomatous uveitis and no systemic sarcoid.
Compared ACE levels with a control group of uveitis patients with known etiologies.

Main Results:

Five out of ten patients with chronic granulomatous uveitis and no systemic sarcoidosis exhibited elevated serum ACE levels.
Ten patients with uveitis of known etiology showed no elevated serum ACE levels.

Conclusions:

Elevated serum ACE levels in conjunction with chronic granulomatous uveitis suggest a diagnosis of ocular sarcoidosis.
Serum ACE measurement may serve as a valuable biomarker for ocular sarcoidosis in the absence of systemic manifestations.

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