Related Experiment Video
Updated: May 19, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
Incompatible kidney transplantation: a brief overview of the past, present and future
A Sharif1, N Alachkar, E Kraus
1Renal Institute of Birmingham, Queen Elizabeth Hospital, Edgbaston, Mindelsohn Way, Birmingham, B15 2WB, UK. sharif_adnan@hotmail.com
QJM : Monthly Journal of the Association of Physicians
|August 22, 2012
Summary
Live kidney transplantation across immunological barriers, including ABO-incompatible and HLA-incompatible kidney transplantation, is now common. Evolving desensitization strategies and paired donation schemes offer new options for patients previously excluded from transplants.
Area of Science:
- Nephrology
- Immunology
- Transplantation Medicine
Background:
- Kidney transplantation is limited by immunological barriers such as ABO and HLA incompatibility.
- Historically, patients with these incompatibilities faced prolonged waiting times or were excluded from transplantation.
- Advances in desensitization protocols and kidney paired donation have expanded eligibility.
Purpose of the Study:
- To review the evolution of desensitization strategies for incompatible kidney transplantation.
- To compare current protocols and their outcomes.
- To discuss future directions in the field.
Main Methods:
- Review of desensitization strategies for ABO- and HLA-incompatible kidney transplantation.
- Analysis of kidney paired donation exchange schemes.
- Comparison of outcomes from various desensitization regimens.
Main Results:
- Desensitization protocols and kidney paired donation have significantly increased transplantation opportunities for incompatible recipients.
- Various desensitization strategies are currently employed, with evolving efficacy and outcomes.
- These approaches allow patients to overcome or bypass immunological barriers.
Conclusions:
- Incompatible kidney transplantation is now a widely practiced option due to advancements in desensitization and paired donation.
- Understanding these evolving protocols is crucial for non-transplant clinicians.
- Future directions aim to further refine strategies for successful incompatible kidney transplantation.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...