Related Experiment Video
Updated: May 19, 2026

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
Published on: February 6, 2014
Dose response of xylitol and sorbitol for EPR retrospective dosimetry with applications to chewing gum
A Israelsson1, H Gustafsson, E Lund
1Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping SE 581 85, Sweden. axel.israelsson@liu.se
Abstract:
The purpose of this investigation was to study the radiation-induced electron paramagnetic resonance signal in sweeteners xylitol and sorbitol for use in retrospective dosimetry. For both sweeteners and chewing gum, the signal changed at an interval of 1-84 d after irradiation with minimal changes after 4-8 d. A dependence on storage conditions was noticed and the exposure of the samples to light and humidity was therefore minimised. Both the xylitol and sorbitol signals showed linearity with dose in the measured dose interval, 0-20 Gy. The dose-response measurements for the chewing gum resulted in a decision threshold of 0.38 Gy and a detection limit of 0.78 Gy. A blind test illustrated the possibility of using chewing gums as a retrospective dosemeter with an uncertainty in the dose determination of 0.17 Gy (1 SD).
Related Concept Videos
Dose Response Curve: Conventional Versus Nonmonotonic
Dose-Response Relationship: Potency and Efficacy
Dose-Response Relationship: Overview
Oral Drug Delivery Systems: Introduction
