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Related Experiment Video

Updated: May 19, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Executive resting-state network connectivity in migraine without aura.

Antonio Russo¹, Alessandro Tessitore, Alfonso Giordano

¹Department of Neurological Sciences, Second University of Naples, Naples 80138, Italy.

Cephalalgia : an International Journal of Headache

|August 22, 2012

Summary

Migraine patients show reduced fronto-parietal network connectivity, even without obvious executive function deficits. This reduced connectivity in the middle frontal gyrus correlates with migraine pain intensity.

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Area of Science:

Neuroscience
Medical Imaging
Neurology

Background:

Converging evidence suggests executive functions (EF) may be impaired in migraine patients during interictal periods.
Migraine without aura (MwoA) is a common neurological disorder.
Fronto-parietal networks (FPN) are crucial for executive functions.

Purpose of the Study:

To evaluate functional connectivity within the fronto-parietal networks (FPN) in MwoA patients during the interictal period.
To compare FPN functional connectivity between MwoA patients and healthy controls (HC).
To assess the relationship between FPN functional connectivity, MwoA clinical features, and executive functions.

Main Methods:

Resting-state functional MRI (RS-fMRI) was used to compare FPN functional connectivity.
14 MwoA patients and 14 age- and sex-matched HC participated.
Voxel-based morphometry was employed to investigate structural differences.

Main Results:

No significant executive dysfunction was detected in MwoA patients through neuropsychological testing.
MwoA patients exhibited reduced functional connectivity within the right FPN, specifically in the middle frontal gyrus (MFG) and dorsal anterior cingulate cortex, compared to HC.
Reduced MFG connectivity negatively correlated with migraine pain intensity; no structural differences were found between groups.

Conclusions:

MwoA is associated with reduced FPN functional connectivity, even without clinically apparent EF deficits.
These findings offer insights into the underlying mechanisms of migraine.
The study highlights potential neural correlates of migraine beyond overt cognitive impairment.