Related Experiment Video

Updated: May 19, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

[Impact of diabetes in children and adolescents]

Pilar Isla Pera1

  • 1Department Enfermería de Salud Pública, Salud Mental y Materno Infantil, EUE, Universidad de Barcelona. pisla@ub.edu

Revista De Enfermeria (Barcelona, Spain)
|August 23, 2012
PubMed

Insights

Type 1 diabetes (DM 1) most frequently affects children under 15, especially preschoolers and pre-pubertal individuals. This autoimmune condition necessitates lifelong insulin therapy due to pancreatic beta-cell destruction.

Area of Science:

  • Endocrinology
  • Immunology
  • Pediatrics

Context:

  • Type 1 diabetes (DM 1) is a chronic autoimmune condition.
  • It is characterized by the destruction of pancreatic beta cells, leading to absolute insulin deficiency.
  • DM 1 is a significant health concern in pediatric populations worldwide.

Purpose:

  • To summarize the key epidemiological and clinical features of Type 1 diabetes in children and adolescents.
  • To highlight the age-specific incidence and the necessity of insulin treatment from diagnosis.

Summary:

  • Type 1 diabetes (DM 1) can occur at any age but shows a higher incidence in individuals under 15 years, particularly in preschool and pre-pubertal age groups.
  • DM 1 accounts for approximately 10% of all diabetes mellitus cases and is a prevalent chronic condition among children and adolescents.
  • The autoimmune destruction of pancreatic beta cells results in a complete lack of insulin, mandating lifelong insulin replacement therapy from the point of diagnosis.

Impact:

  • Provides essential information for understanding the prevalence and management of pediatric Type 1 diabetes.
  • Emphasizes the critical need for early diagnosis and consistent insulin therapy in affected children.
  • Contributes to the knowledge base for developing targeted interventions and support for young individuals with diabetes.

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.