Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer-Aided Diagnosis of Colorectal Polyps: Clinical Usefulness and Limitations.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2025
Same author

Forging forward: SG60 and Changi General Hospital at 90.

Singapore medical journal·2025
Same author

Improving uptake of telemedicine (phone/video consult): methods and lessons learnt.

BMJ open quality·2025
Same author

Minimal monitoring is a safe but underutilised strategy for hepatitis C virus management in Singapore.

Annals of the Academy of Medicine, Singapore·2024
Same author

Real-World Validation of a Computer-Aided Diagnosis System for Prediction of Polyp Histology in Colonoscopy: A Prospective Multicenter Study.

The American journal of gastroenterology·2023
Same author

Helicobacter pylori World Gastroenterology Organization Global Guideline.

Journal of clinical gastroenterology·2023

Related Experiment Video

Updated: May 19, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Nutritional support in acute pancreatitis.

Jeannie P L Ong1, Kwong Ming Fock

  • 1Department of Gastroenterology, Changi General Hospital, Singapore. jeannie_ong@cgh.com.sg

Journal of Digestive Diseases
|August 23, 2012
PubMed
Summary

Nutritional support is crucial for severe acute pancreatitis. Early enteral nutrition (EN) significantly reduces complications and mortality compared to parenteral nutrition, improving patient outcomes.

Area of Science:

  • Gastroenterology and Clinical Nutrition
  • Critical Care Medicine

Background:

  • Acute pancreatitis ranges from mild to severe, with severe cases causing high metabolism and protein catabolism.
  • Nutritional management in severe acute pancreatitis is challenging, aiming to meet metabolic demands while preserving gut integrity and avoiding pancreatic stimulation.
  • The traditional concept of 'pancreatic rest' has evolved with advancements in nutritional strategies.

Purpose of the Study:

  • To review current knowledge on nutritional management in acute pancreatitis.
  • To highlight the benefits of enteral nutrition (EN) over parenteral nutrition (PN) in severe cases.
  • To share local experiences in managing nutrition for acute pancreatitis patients.

Main Methods:

  • Review of existing scientific literature on nutrition in acute pancreatitis.

More Related Videos

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Related Experiment Videos

Last Updated: May 19, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

  • Analysis of comparative studies between enteral and parenteral nutrition.
  • Synthesis of clinical experience and data.

    • Main Results:

    • Enteral nutrition (EN) is scientifically proven to significantly reduce infectious complications, surgical interventions, and mortality in predicted severe acute pancreatitis compared to parenteral nutrition (PN).
    • Early initiation of EN may lead to improved outcomes in patients with severe acute pancreatitis.
    • Nutritional support must balance metabolic demands with the need to minimize pancreatic stimulation and maintain gut function.

    Conclusions:

    • Enteral nutrition is the preferred route for nutritional support in severe acute pancreatitis.
    • Early EN administration is associated with better patient outcomes.
    • Optimizing nutritional strategies is key to managing the complexities of severe acute pancreatitis.