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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Published on: February 14, 2017

Age dependency of coagulation parameters during childhood and puberty

I M Appel1, B Grimminck, J Geerts

  • 1Paediatric Haematology, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam Laboratory of Paediatric Haemostasis, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, the Netherlands.

Journal of Thrombosis and Haemostasis : JTH
|August 23, 2012
PubMed

Insights

Establishing age-specific reference ranges for coagulation tests is vital for diagnosing pediatric bleeding disorders. This study highlights significant age-related differences in key hemostatic factors, particularly in infants and young children.

Area of Science:

  • Pediatric Hematology
  • Clinical Coagulation
  • Hemostasis and Thrombosis

Background:

  • Accurate diagnosis of pediatric thrombotic and hemorrhagic disorders relies on age-adjusted reference values for coagulation tests.
  • Existing reference values can vary significantly based on the reagents and analyzers used, necessitating standardized evaluations.

Purpose of the Study:

  • To establish age-specific reference values for coagulation parameters using the Sysmex CA-1500 and Behring BCS systems.
  • To compare the performance of these two widely used analytical systems for pediatric coagulation testing.

Main Methods:

  • Blood samples were collected from 218 healthy children across various age groups (1 month to 18 years) and 52 healthy adults.
  • Coagulation parameters were measured using Siemens Healthcare Diagnostics reagents on both Sysmex CA-1500 and Behring BCS systems.

Main Results:

  • Good comparability was observed between the two analyzers for most coagulation parameters, except for Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT).
  • Significant age-dependent decreases were noted for fibrinogen, factors II, IX, XI, and XII in younger children.
  • Coagulation inhibitors Protein C and S, and von Willebrand factor showed the most pronounced age-related variations, with distinct patterns in infancy and early childhood.

Conclusions:

  • The study confirmed remarkable correlation between the Sysmex CA-1500 and Behring BCS systems.
  • Significant differences in coagulation parameters were most pronounced between infants (<12 months) and older children/adults, underscoring developmental hemostasis.
  • The findings emphasize the critical need for age-specific reference ranges in pediatric coagulation testing to ensure accurate clinical management.
Abstract

Keywords:
childrendevelopmental hemostasisreference values

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