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Asparaginase-associated pancreatitis in children
Raheel Altaf Raja1, Kjeld Schmiegelow, Thomas Leth Frandsen
1The Department of Paediatrics and Adolescent Medicine, the University Hospital Rigshospitalet, Copenhagen, Denmark.
British Journal of Haematology
|August 23, 2012
Summary
L-asparaginase is crucial for treating leukemia and lymphoma but can cause pancreatitis, a common reason for treatment cessation. This review details pancreatitis risks, symptoms, and management in patients receiving L-asparaginase therapy.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- L-asparaginase is a vital chemotherapeutic agent for acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma.
- Therapy with L-asparaginase is associated with significant toxicities, including pancreatitis, allergic reactions, and hepatotoxicity.
Purpose of the Study:
- To review the definition, risk factors, treatment, and complications of L-asparaginase-associated pancreatitis.
- To highlight acute pancreatitis as a major dose-limiting toxicity of L-asparaginase treatment.
Main Methods:
- Literature review of studies on L-asparaginase-associated pancreatitis.
- Analysis of clinical and genetic risk factors for pancreatitis.
- Examination of short-term and long-term complications.
Main Results:
- Acute pancreatitis is a frequent reason for discontinuing L-asparaginase therapy.
- Complications range from pseudocysts and necrosis to chronic pancreatitis and diabetes.
- Current risk factors are weak predictors of pancreatitis development.
Conclusions:
- Understanding L-asparaginase-associated pancreatitis is crucial for patient management.
- Further research into pathophysiology and predictive factors is needed to optimize treatment.
- Effective management strategies are essential to mitigate severe complications.
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