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Updated: May 19, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

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Published on: February 14, 2017

Decrease in endothelial progenitor cells associated with inflammation, but not with endothelial dysfunction in

Abdullah Ozkok1, Esin Aktas, Akar Yilmaz

  • 1Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.

Clinical Nephrology
|August 23, 2012
PubMed
Summary
This summary is machine-generated.

Endothelial progenitor cell (EPC) numbers are reduced in hemodialysis patients and linked to inflammation, particularly TNF-α. EPC levels did not correlate with endothelial dysfunction or atherosclerosis markers in this study.

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Published on: September 22, 2020

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Cell Biology

Background:

  • Endothelial progenitor cells (EPCs) are crucial for endothelial repair.
  • Uremia is associated with endothelial dysfunction, atherosclerosis, and inflammation, increasing cardiovascular mortality.
  • The role of EPCs in chronic hemodialysis (HD) patients remains unclear.

Purpose of the Study:

  • To investigate the association between EPCs and inflammation, endothelial dysfunction, and atherosclerosis in HD patients.
  • To explore the relationship between EPC markers and inflammatory markers.
  • To assess the correlation of EPCs with endothelial function and atherosclerosis indicators.

Main Methods:

  • Cultured and counted EPCs from 67 HD patients and 22 controls.
  • Analyzed EPC markers (CD34, CD133, VEGFR-2) via flow cytometry.
  • Measured serum inflammatory markers (IL-6, TNF-α, ICAM, VCAM) and ADMA.
  • Assessed endothelial function (FMD) and atherosclerosis (CIMT, CIMR).

Main Results:

  • HD patients had significantly lower EPC numbers and CD34+ cell counts compared to controls.
  • EPC count inversely correlated with serum TNF-α and IL-6 levels in HD patients.
  • No significant association was found between EPC count and FMD, CIMT, or CIMR.
  • Serum IL-6 positively correlated with CIMT, and CIMR positively correlated with ICAM in HD patients.

Conclusions:

  • Uremia is associated with reduced EPC numbers and increased inflammation.
  • TNF-α may inhibit EPCs in both HD patients and healthy individuals.
  • EPCs are not directly related to endothelial dysfunction or atherosclerosis in this HD patient cohort.