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Updated: May 19, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

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Published on: July 19, 2019

Multiple sclerosis and pain.

Saeed Talebzadeh Nick1, Charles Roberts, Seth Billiodeaux

  • 1Department of Neurology, LSU Health Sciences Center, Shreveport, LA, USA.

Neurological Research
|August 23, 2012
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is often mistakenly viewed as painless, but many patients experience significant pain from neuropathy, spasms, and MS relapses. Effective pain management in MS remains a complex clinical challenge.

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Area of Science:

  • Neurology
  • Pain Medicine

Background:

  • Multiple sclerosis (MS) is commonly misperceived as a painless condition.
  • However, a substantial number of MS patients suffer from various painful conditions, including neuropathic pain, migraines, and spasms.

Purpose of the Study:

  • To review recent findings on the pathophysiology of pain in MS.
  • To explore current management strategies for pain in MS patients.

Main Methods:

  • Literature review of recent studies on MS pain.
  • Analysis of pain conditions, pathophysiology, and treatment approaches.

Main Results:

  • MS patients experience diverse painful conditions, such as central/peripheral neuropathy, trigeminal neuralgia, and painful tonic spasms.
  • MS relapses frequently involve pain, including neuropathic pain and paroxysmal dystonia.
  • Potential pathophysiological links include demyelinating lesions affecting neuroanatomic pathways like the spinothalamic tract.
  • Treatment involves pharmacological agents (antiepileptics, NSAIDs, corticosteroids) and non-pharmacological methods (massage therapy).

Conclusions:

  • Pain is a significant and often underestimated symptom in multiple sclerosis.
  • Understanding the pathophysiology is crucial for effective pain management, which remains a therapeutic challenge.