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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...

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Related Experiment Video

Updated: May 19, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

TRP channels and analgesia.

Louis S Premkumar1, Mruvil Abooj

  • 1Department of Pharmacology, Southern Illinois University School of Medicine Springfield, IL 62702, USA. lpremkumar@siumed.edu

Life Sciences
|August 23, 2012
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential (TRP) channels, including TRPV1 and TRPA1, are key targets for novel pain relief. However, their roles in physiological functions necessitate careful consideration of potential side effects from TRP channel modulators.

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Last Updated: May 19, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Transient Receptor Potential (TRP) channels are crucial for nociception, detecting noxious stimuli.
  • Several TRP channel subtypes (TRPV1-4, TRPA1, TRPM8, TRPC1, 5, 6, TRPM2, 3) are expressed in sensory neurons.
  • These channels are modulated by inflammatory mediators, influencing pain signaling.

Purpose of the Study:

  • To review the role of TRP channels as therapeutic targets for pain management.
  • To discuss the potential of TRP channels in developing next-generation analgesics.
  • To examine the side effects associated with targeting TRP channels due to their physiological roles.

Main Methods:

  • Literature review of TRP channel research.
  • Analysis of TRP channel expression in nociceptors.
  • Discussion of pharmacological modulation (antagonists/agonists) of TRP channels.

Main Results:

  • TRP channels mediate thermal, mechanical, and chemical sensitivities.
  • TRP channels are implicated in pain pathways and modulated by inflammatory signals.
  • Targeting TRP channels offers potential for analgesia but carries risks due to physiological involvement.

Conclusions:

  • TRP channels represent promising targets for novel analgesic therapies.
  • Understanding the dual role of TRP channels in pain and physiology is critical for drug development.
  • Careful therapeutic strategies are needed to balance efficacy and side effects when targeting TRP channels.