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Quantitative detection of single DNA molecules on DNA tetrahedron decorated substrates

Zhenguang Wang1, Qingwang Xue, Wenzhi Tian

  • 1Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China.

Chemical Communications (Cambridge, England)
|August 23, 2012
PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...