Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deletion of endothelial SOX9 reverses aging-induced cardiac dysfunction.

Cardiovascular research·2026
Same author

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer.

British journal of pharmacology·2026
Same author

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.

Nature metabolism·2026
Same author

Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation.

Cell metabolism·2025
Same author

Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease.

Nature communications·2025
Same author

Decor(at)i(o)n: less is more?

Cardiovascular research·2025

Related Experiment Video

Updated: May 19, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

Finding good biomarkers for sarcopenia.

Gesine Scharf1, Joerg Heineke

  • 1Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth-Cluster of Excellence, Carl-Neuberg Str.1, 30625, Hannover, Germany.

Journal of Cachexia, Sarcopenia and Muscle
|August 23, 2012
PubMed
Summary
This summary is machine-generated.

Sarcopenia, the age-related loss of muscle, affects everyone but can lead to severe health issues. New biomarkers combining blood tests, imaging, and function tests are needed to identify and treat pathological sarcopenia.

More Related Videos

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Related Experiment Videos

Last Updated: May 19, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Area of Science:

  • Gerontology
  • Muscle physiology
  • Biomarker discovery

Background:

  • Sarcopenia is the age-related loss of skeletal muscle mass and function, beginning around age 40.
  • While common, sarcopenia can lead to disability, illness, and mortality in some individuals.
  • Current methods cannot reliably distinguish between physiological and pathological sarcopenia.

Purpose of the Study:

  • To highlight the need for reliable and cost-effective biomarkers for sarcopenia.
  • To propose an ideal biomarker panel for diagnosing and treating pathological sarcopenia.
  • To emphasize the necessity of clinical validation for sarcopenia biomarkers.

Main Methods:

  • Literature review and expert consensus on sarcopenia diagnosis.
  • Proposal of a multi-modal biomarker approach.
  • Emphasis on the need for clinical trial validation.

Main Results:

  • A significant gap exists in differentiating physiological from pathological sarcopenia.
  • A combination of serum markers, diagnostic imaging, and muscle function tests is proposed as an ideal biomarker panel.
  • Clinical validation in trials is crucial for sarcopenia biomarker development.

Conclusions:

  • Reliable biomarkers are essential for managing pathological sarcopenia.
  • A multi-modal approach offers a promising strategy for sarcopenia biomarker development.
  • Future research must focus on rigorous clinical validation of proposed biomarkers.