Related Experiment Video

Updated: May 19, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Relationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitus

Serdal Korkmaz1, Abdulkerim Yilmaz, Gürsel Yildiz

  • 1Division of Hematology, Cumhuriyet University School of Medicine, Sivas, Turkey.

Arquivos Brasileiros De Endocrinologia E Metabologia
|August 23, 2012
PubMed

Insights

Higher homocystein levels were observed in non-dipper patients with type 2 diabetes mellitus and in the control group. However, no significant difference was found between dipper and non-dipper groups regarding homocystein levels.

Area of Science:

  • Cardiology
  • Endocrinology
  • Vascular Biology

Background:

  • Type 2 diabetes mellitus (type 2 DM) is associated with a reduced rate of nocturnal blood pressure (NBP) reduction.
  • Hyperhomocysteinemia (HHC) negatively impacts vascular structure and function.
  • Diabetic patients with HHC face an elevated risk of vascular disease.

Purpose of the Study:

  • To investigate potential differences in homocystein levels between dipper and non-dipper patients with type 2 DM.
  • To explore the relationship between nocturnal blood pressure patterns and homocystein levels in type 2 DM.

Main Methods:

  • A comparative study involving 50 patients with type 2 DM and 35 healthy controls.
  • Ambulatory blood pressure monitoring (ABPM) was conducted for all participants.
  • Homocysteine levels were measured in all subjects.

Main Results:

  • The non-dipper pattern was more prevalent in type 2 DM patients (72%) compared to controls (57%).
  • Homocysteine levels were higher in non-dipper individuals (13.4 ± 8.1 µmol/L in type 2 DM, 11.8 ± 5 µmol/L in controls) than in dipper individuals (11.8 ± 5.8 µmol/L in type 2 DM, 10.1 ± 4.2 µmol/L in controls).
  • No statistically significant difference in homocystein levels was observed between dipper and non-dipper groups in either type 2 DM patients (p = 0.545) or controls (p = 0.294).

Conclusions:

  • While homocystein levels trended higher in non-dippers, this difference was not statistically significant in either group.
  • Both high homocystein levels and the non-dipper blood pressure pattern are recognized contributors to increased cardiovascular risk.
  • Further research with larger cohorts is warranted to elucidate the relationship between nocturnal blood pressure variations and homocystein levels.
Abstract

Related Concept Videos

Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...