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[Patient with type II membranoproliferative glomerulonephritis: intravitreal bevacizumab therapy for choroidal

M Karampelas1, N Kopsachilis, J H Chang

  • 1Moorfields Eye Hospital, 162 City Road, London, UK.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|August 23, 2012
PubMed

Insights

Membranoproliferative glomerulonephritis (MPGN) type II can cause vision loss. A single bevacizumab injection successfully treated choroidal neovascularization in one patient with MPGN type II, with no recurrence at six months.

Area of Science:

  • Ophthalmology
  • Nephrology
  • Pathology

Background:

  • Membranoproliferative glomerulonephritis (MPGN) type II is a rare kidney disease.
  • MPGN type II involves electron-dense deposits in the glomeruli and Bruch's membrane.
  • Ocular complications, including choroidal neovascularization, can affect visual acuity.

Observation:

  • A patient with MPGN type II presented with choroidal neovascularization.
  • Choroidal neovascularization can lead to permanent vision impairment.

Findings:

  • Successful treatment of choroidal neovascularization with a single intravitreal bevacizumab injection.
  • No recurrence of choroidal neovascularization observed during a 6-month follow-up period.

Implications:

  • Intravitreal bevacizumab may be an effective treatment for choroidal neovascularization in MPGN type II patients.
  • This case highlights a potential therapeutic option for vision-threatening complications of MPGN type II.
  • Further research is warranted to confirm the efficacy and long-term outcomes of bevacizumab in this condition.

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