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Related Concept Videos

Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse.
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...

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NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
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NMR View: A computer program for the visualization and analysis of NMR data.

B A Johnson1, R A Blevins

  • 1Department of Biophysical Chemistry, Merck Research Laboratories, RY80Y-103, P.O. Box 2000, 07065, Rahway, NJ, USA.

Journal of Biomolecular NMR
|August 23, 2012
PubMed
Summary

NMR View is a versatile computer program for nuclear magnetic resonance (NMR) data analysis. It facilitates the visualization and interpretation of complex NMR spectra, aiding in molecular structure determination.

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Last Updated: May 19, 2026

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Area of Science:

  • Chemistry
  • Biochemistry
  • Structural Biology

Background:

  • Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for determining molecular structure.
  • Analyzing large and complex NMR datasets can be challenging and time-consuming.
  • Effective visualization and analysis tools are crucial for efficient NMR data interpretation.

Purpose of the Study:

  • To introduce NMR View, a comprehensive software for NMR data visualization and analysis.
  • To highlight the program's capabilities in handling multi-dimensional NMR data.
  • To demonstrate how NMR View facilitates spectral analysis and structure generation integration.

Main Methods:

  • NMR View supports interaction with numerous 2D, 3D, and 4D NMR data files.
  • Features include customizable spectral window display, automatic peak picking, and facilitated peak analysis.
  • Integration with structure generation programs and a molecular graphics viewer (Molecular Data Viewer) for visual correlation.
  • A command language allows for task automation and user interface customization.

Main Results:

  • NMR View enables the visualization and analysis of extensive NMR datasets.
  • Automated and facilitated features streamline the assignment of complex NMR spectra.
  • Seamless data transfer and visual correlation enhance the link between spectral analysis and structure generation.
  • Customizable interface and command language offer flexibility and automation for users.

Conclusions:

  • NMR View provides a robust platform for advanced NMR data analysis.
  • The software simplifies the process of spectral assignment and structure elucidation.
  • NMR View's integrated approach enhances the efficiency of molecular structure determination using NMR data.