Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Intratumor microbiota as a novel potential prognostic indicator in mesothelioma.

Frontiers in immunology·2025
Same author

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma.

Frontiers in immunology·2023
Same author

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

RSC advances·2022
Same author

Elimination of Off-Target Effect by Chemical Modification of 5'-End of siRNA.

Nucleic acid therapeutics·2022
Same author

Comparison of 3 Randomized Clinical Trials of Frontline Therapies for Malignant Pleural Mesothelioma.

JAMA network open·2022
Same author

Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies.

International journal of oncology·2022

Related Experiment Video

Updated: May 19, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Roadmap to personalized medicine.

Malak Qattan1, Constantinos Demonacos, Marija Krstic-Demonacos

  • 1Marija Krstic-Demonacos, Faculty of Life Sciences, The University of Manchester, Manchester, UK.

Croatian Medical Journal
|August 23, 2012
PubMed
Summary

Personalized medicine tailors treatments to individual patient needs, improving effectiveness and reducing adverse drug effects. Overcoming challenges requires advancements in data consistency, technology, education, and industry/legal reforms for widespread clinical adoption.

More Related Videos

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine
06:14

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Published on: September 19, 2025

Related Experiment Videos

Last Updated: May 19, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine
06:14

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Published on: September 19, 2025

Area of Science:

  • Translational medicine
  • Genomics and bioinformatics
  • Clinical pharmacology

Background:

  • Current "one drug fits all" approaches are often ineffective, particularly in cancer treatment where 75% of therapies fail.
  • The limitations of standardized treatments highlight the need for individualized patient care strategies.

Purpose of the Study:

  • To explore strategies for implementing personalized medicine in clinical practice.
  • To identify challenges and propose solutions for data consistency, technological integration, and educational reform.

Main Methods:

  • Discussion of approaches to enhance data consistency from basic research for medical application.
  • Highlighting the role of systems biology and computational approaches in overcoming scientific hurdles.
  • Addressing necessary changes in education, industry focus, and legal frameworks.

Main Results:

  • Personalized medicine offers potential for novel therapies, reduced adverse drug effects, and optimized patient treatments.
  • Advancements in technology and data analysis are crucial for realizing the benefits of individualized care.
  • Multifaceted changes are required, including educational shifts and industry/legal adaptations.

Conclusions:

  • Successful implementation of personalized medicine requires a collaborative effort from researchers, healthcare professionals, and policymakers.
  • A coordinated roadmap is essential for the safe and rapid transition to effective, individualized treatments.
  • Personalized medicine promises to revolutionize healthcare, leading to disease elimination and improved patient outcomes.