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Updated: May 19, 2026
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Published on: April 1, 2018
Cortical Thickness in Young Treatment-Naive Children With ADHD
Xiao-Ru Yang1, Normand Carrey2, Denise Bernier2
1University of Calgary, Alberta, Canada.
Objective:
This study aimed to investigate the cortical thickness in areas of the brain that are hypothesized to be involved in response inhibition and error-monitoring behaviors. The authors hypothesized that children with ADHD would have a thinner prefrontal cortex (PFC) and anterior cingulate cortex (ACC) than healthy children.
Method:
In all, 25 ADHD and 25 healthy control male children (5-12 years) underwent magnetic resonance imaging.
Results:
The authors found thinner right superior frontal gyrus in ADHD patients compared with controls (t = 2.01, df = 45, p = .049). The older children with ADHD drove this effect when participants were further subdivided into a younger and older age group (older participants: p = .004; younger participants: p = ns).
Conclusion:
These findings have implications for the developmental trajectory of the frontal lobe in ADHD.
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