Related Experiment Videos
[Specific proteinase plasma sorption in surgery with artificial blood circulation]
Vestnik Akademii Meditsinskikh Nauk SSSR
|January 1, 1990
Summary
Cardiosurgery using artificial circulation activates plasma enzymes, causing complications. A new sorption method using a human urine proteinase inhibitor prevents this activation, improving patient recovery and reducing risks.
Area of Science:
- Biochemistry
- Cardiovascular Surgery
- Nephrology
Background:
- Cardiosurgery involving artificial circulation (AC) triggers plasma cascade proteolytic systems.
- This activation results in homeostatic disturbances and increases the risk of postoperative complications.
Purpose of the Study:
- To investigate the efficacy of specific proteinase plasma sorption in preventing AC-induced complications.
- To evaluate the impact of this method on plasma protein restoration and patient outcomes.
Main Methods:
- Utilizing a column with sepharose-immobilized acid-base proteinase inhibitor from human urine for plasma sorption.
- Monitoring plasma proteinase activation and concentration during and after AC.
Main Results:
- Specific proteinase plasma sorption effectively prevented proteinase activation in the plasma during AC.
- The method led to rapid restoration of plasma protein concentrations reduced by AC.
- Patients experienced an improved postoperative period with reduced pulmonary, cardiovascular, and nervous complications.
Conclusions:
- Specific proteinase plasma sorption is a promising method to mitigate AC-related complications.
- This technique enhances recovery and reduces the incidence of adverse events following cardiosurgery.
- The use of human urine-derived proteinase inhibitors offers a targeted approach to managing cascade proteolytic system activation.