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Related Experiment Video

Updated: May 19, 2026

In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation

In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation

Published on: April 30, 2014

Does the central dogma still stand?

Eugene V Koonin¹

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. koonin@ncbi.nlm.nih.gov

|August 24, 2012

Summary

This summary is machine-generated.

Prions, proteins with unique inheritance, can benefit cells under stress. This protein-based information flow to the genome challenges the Central Dogma, influencing evolution.

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Area of Science:

Molecular Biology
Genetics
Evolutionary Biology

Background:

Prions are protein-based inheritance agents conferring beneficial phenotypes, particularly under cellular stress.
Prion-mediated inheritance can integrate with genetic variation, leading to stable, prion-independent genomic inheritance.
Recent screenings indicate prions are prevalent, especially in fungal species.

Purpose of the Study:

To investigate the role of prions in information flow from proteins to the genome.
To explore how prion-mediated heredity challenges the Central Dogma of molecular biology.
To understand the contribution of epigenetic variation to genetic adaptation and evolution.

Main Methods:

Analysis of prion prevalence through screening studies.
Theoretical examination of prion-mediated inheritance mechanisms.
Comparative analysis of protein-based and genetic inheritance.

Main Results:

Prions facilitate a non-negligible flow of information from proteins to the genome, violating the Central Dogma.
Prion-mediated heredity represents a radical form of epigenetic variation assimilation into genetic variation.
Epigenetic variation, including prions, can precede and facilitate genetic adaptation via a 'look-ahead effect'.

Conclusions:

The flow of information from proteins to the genome via prions is a significant biological phenomenon.
Prion-mediated heredity contributes to the evolution of complex adaptive traits and environment-genome interactions.
This mechanism highlights a broader pathway for epigenetic variation to influence genetic adaptation, challenging traditional molecular biology paradigms.