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Related Experiment Videos

Intersubnuclear connections within the rat trigeminal brainstem complex.

M F Jacquin1, N L Chiaia, J H Haring

  • 1Department of Anatomy and Neurobiology, St. Louis University School of Medicine, Missouri 63104.

Somatosensory & Motor Research
|January 1, 1990
PubMed
Summary
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This study maps neuronal connections within the rat trigeminal brainstem nuclear complex (TBNC). Findings reveal that most intersubnuclear axons originate from local-circuit neurons, with some projecting to the midbrain and diencephalon.

Area of Science:

  • Neuroscience
  • Neuroanatomy

Background:

  • Previous studies using intracellular recording and labeling identified local-circuit and projection neurons in the spinal trigeminal (V) nucleus.
  • These neurons have axons that arborize in rostral and caudal subnuclei and nucleus principalis.

Purpose of the Study:

  • To investigate the origin, extent, distribution, and morphology of intersubnuclear axons within the rat trigeminal brainstem nuclear complex (TBNC).
  • To identify the neuronal populations responsible for these intersubnuclear projections.

Main Methods:

  • Anterograde tracing using Phaseolus vulgaris leucoagglutinin (PHA-L) to map axonal projections.
  • Retrograde tracing with horseradish peroxidase (HRP) and fluorescent tracers to identify projecting neurons.

Main Results:

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  • Subnucleus caudalis injections yielded dense labeling in rostral ipsilateral subnuclei.
  • Subnucleus interpolaris projected heavily to magnocellularis caudalis, oralis, and principalis.
  • Neurons in caudalis, interpolaris, and oralis projected to nucleus principalis, thalamus, and/or colliculus.

Conclusions:

  • Most intersubnuclear axons in the TBNC originate from local-circuit neurons.
  • Some intersubnuclear axons arise from neurons with projections to the midbrain and diencephalon.
  • Findings support and extend previous data from intracellular recording and HRP labeling studies.