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Related Experiment Video

Updated: May 19, 2026

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

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Published on: December 14, 2020

[A man who could only sleep sitting].

Renske J Schimmel¹, Jan Stolk, Michel I M Versteegh

¹Gelre Ziekenhuis, afd. Intensive Care, Apeldoorn, the Netherlands.

Nederlands Tijdschrift Voor Geneeskunde

|August 24, 2012

Summary

Bilateral diaphragm paralysis can cause respiratory failure. Surgical diaphragm plication successfully weaned two patients from mechanical ventilation, with one showing further improvement after contralateral diaphragm plication.

Area of Science:

Pulmonology
Thoracic Surgery
Critical Care Medicine

Background:

Bilateral diaphragm paralysis presents significant challenges, often leading to supine-dependent sleep failure, severe hypercapnia, and respiratory failure.
Patients with this condition frequently require mechanical ventilation and may not respond adequately to non-invasive ventilation methods.

Observation:

Two cases of severe bilateral diaphragm paralysis requiring mechanical ventilation are presented.
These patients did not respond to intermittent non-invasive ventilation, necessitating alternative treatment strategies.

Findings:

Unilateral diaphragm plication successfully enabled mechanical ventilation weaning in both subjects.
One patient experienced additional improvement after contralateral diaphragm plication for the other paralyzed hemidiaphragm.

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Decompression of a chronically atelectatic left lower lung lobe led to rapid improvements in ventilation and gas exchange.

Implications:

Diaphragm plication offers a viable surgical option for managing respiratory failure due to bilateral diaphragm paralysis.
Addressing chronic lung complications, such as atelectasis, alongside diaphragm dysfunction can significantly enhance respiratory outcomes.
These findings suggest a potential pathway for improving quality of life and reducing ventilator dependence in affected patients.