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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Updated: May 19, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Crohn's disease.

Daniel C Baumgart1, William J Sandborn

  • 1Department of Medicine, Division of Gastroenterology and Hepatology, Charité Medical Centre, Virchow Hospital, Medical School of the Humboldt-University of Berlin, Berlin, Germany. daniel.baumgart@charite.de

Lancet (London, England)
|August 24, 2012
PubMed
Summary
This summary is machine-generated.

Crohn's disease involves immune system dysfunction triggered by genetics and environment, leading to gastrointestinal and systemic inflammation. Early diagnosis and targeted therapies are crucial for managing this chronic condition.

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Area of Science:

  • Gastroenterology and Immunology
  • Chronic Inflammatory Diseases

Background:

  • Crohn's disease is a relapsing systemic inflammatory condition impacting the GI tract and causing extraintestinal manifestations.
  • Genetic and environmental factors trigger immune dysregulation, affecting both innate and adaptive immunity.

Purpose of the Study:

  • To provide a comprehensive overview of Crohn's disease, including its epidemiology, immunobiology, and natural history.
  • To outline new treatment goals, risk stratification, and evidence-based diagnostic and management strategies.
  • To explore evolving therapeutic targets and preventive measures for Crohn's disease.

Main Methods:

  • Review of genome-wide association studies (GWAS) identifying susceptibility loci.
  • Analysis of innate immune pathways (intestinal barrier, microbial recognition) and adaptive immune responses (T cells, cytokines).
  • Discussion of diagnostic work-up algorithms, advanced imaging (endoscopy, ultrasound, MRI, CT), and biomarkers.

Main Results:

  • GWAS reveal genetic predispositions interacting with environmental factors to disrupt immune homeostasis.
  • Key immune dysfunctions include impaired intestinal barrier, altered microbial recognition, and T cell imbalances.
  • Diminished commensal microbiota diversity is associated with Crohn's disease pathogenesis.

Conclusions:

  • Understanding the complex interplay of genetic, environmental, and immune factors is key to Crohn's disease management.
  • Novel therapeutic targets like integrins and chemokine receptors offer promising treatment avenues.
  • A multi-faceted approach encompassing early diagnosis, risk stratification, and advanced therapies is essential for improving patient outcomes.