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Related Experiment Video

Updated: May 19, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.

K L Kreft¹, E Verbraak, A F Wierenga-Wolf

¹Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Genes and Immunity

|August 24, 2012

Summary

Multiple sclerosis (MS) patients exhibit lower soluble interleukin-7 receptor-alpha (sIL-7Rα) levels and higher membrane-bound IL-7Rα to sIL-7Rα ratios. These changes correlate with the IL-7Rα rs6897932 risk allele and may impact IL-7 signaling in MS.

Related Experiment Videos

Last Updated: May 19, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Area of Science:

Immunology
Neuroimmunology
Genetics

Background:

Polymorphisms in the interleukin-7 receptor-alpha (IL-7Rα)/IL-7 pathway are linked to increased multiple sclerosis (MS) risk.
The rs6897932 single-nucleotide polymorphism (SNP) in IL-7Rα is associated with elevated soluble IL-7Rα (sIL-7Rα) production.

Purpose of the Study:

To investigate the levels of IL-7, membrane-bound IL-7Rα (mIL-7Rα), and sIL-7Rα in MS patients compared to healthy controls (HCs).
To explore the relationship between sIL-7Rα levels, the rs6897932 SNP, and the mIL-7Rα to sIL-7Rα ratio in MS.

Main Methods:

Quantification of IL-7, mIL-7Rα, and sIL-7Rα levels in MS patients and HCs.
Analysis of the correlation between sIL-7Rα levels and the rs6897932 SNP.
Assessment of the mIL-7Rα to sIL-7Rα ratio on CD4 and CD8 T cells.

Main Results:

MS patients displayed significantly lower sIL-7Rα levels than HCs.
sIL-7Rα levels increased with the rs6897932 [C] risk allele in both groups.
MS patients showed a significantly higher mIL-7Rα to sIL-7Rα ratio on T cells.
IL-7 levels were significantly decreased in MS patients.

Conclusions:

MS patients have reduced free IL-7 and an altered IL-7Rα balance (higher membrane-bound to soluble ratio).
The observed alterations in IL-7 and IL-7Rα levels are linked to the rs6897932 SNP.
These molecular changes may influence the responsiveness of IL-7Rα-expressing cells in MS pathogenesis.