Related Experiment Video
Updated: May 19, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Prevalence of electrocardiographic left ventricular hypertrophy in human hypertension: an updated review
Cesare Cuspidi1, Marta Rescaldani, Carla Sala
1Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milano, Italy. cesare.cuspidi@unimib.it
Insights
Left ventricular hypertrophy (LVH) is common in hypertensive patients, affecting an average of 18% of the population. Electrocardiogram (ECG) is a valuable tool for detecting this cardiac organ damage and guiding treatment.
Area of Science:
- Cardiology
- Hypertension Research
- Diagnostic Imaging
Background:
- Left ventricular hypertrophy (LVH) is a significant predictor of cardiovascular events.
- Identifying cardiac organ damage in hypertension is crucial for risk stratification.
Purpose of the Study:
- To review recent studies on the prevalence of hypertensive LVH using ECG.
- To update knowledge on LVH as a marker of cardiac organ damage in hypertension.
Main Methods:
- MEDLINE search for studies on LVH, hypertension, and ECG from 2000-2010.
- Inclusion of 26 studies with over 40,000 adult participants.
- Analysis of LVH prevalence based on various diagnostic criteria.
Main Results:
- LVH prevalence varied widely (0.6-40.0%), averaging 18% in the pooled population.
- Prevalence was higher in men (24%) compared to women (16%).
- The study included diverse patient demographics (whites, obese, diabetics, CVD patients).
Conclusions:
- ECG is effective for identifying subclinical organ damage in hypertensive patients.
- ECG aids in optimizing blood pressure control.
- LVH is present in a substantial portion of the hypertensive population.
Aim:
Left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular events in different clinical settings. We reviewed recent studies on the prevalence of hypertensive LVH, as assessed by ECG, in order to update our knowledge about this marker of cardiac organ damage in human hypertension.
Design:
A MEDLINE search using the key words ' LVH ', 'hypertension', 'ECG', 'cardiac organ damage' and 'cardiac hypertrophy' was performed in order to identify relevant articles. Full articles published in English language in the last decade (1 January 2000 to 31 December 2010) reporting studies in adult or elderly individuals, were considered.
Results:
A total of 26 studies, including 40 444 untreated and treated individuals (85% whites, 47% men, 32% obese, 28% diabetics and 22% patients with cardiovascular disease) were considered. LVH was defined by 15 criteria (seven studies used two or more criteria, range 2-7); LVH prevalence consistently varied among studies (0.6-40.0%) with an average of 18% in the pooled population. A sex-based analysis in five out of 26 studies (12 084 patients) showed an average prevalence of LVH of 24% in men and 16% in women (odds ratio 1.38, 95% CI 0.91-2.09, P = 0.11).
Conclusion:
Our analysis shows that LVH, as assessed by ECG, is present in a relevant fraction of the hypertensive population; these data highlight the role of ECG as a first-line examination for identifying subclinical organ damage and optimizing blood pressure control in hypertensive patients.
More Related Videos
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertension III: Clinical Manifestations and Diagnostic Studies
Heart Failure II: Pathophysiology
Hypertension II: Pathophysiology
Hypertension I: Introduction
Mitral Regurgitation I: Introduction

