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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Targeted agents in second-line bladder cancer therapy

Holger Gerullis1, Thomas Otto, Thorsten H Ecke

  • 1Department of Urology, Lukas Hospital, Neuss, Germany. holger.gerullis@gmx.net

Anti-Cancer Drugs
|August 24, 2012
PubMed

Insights

Targeted therapies show limited success in second-line urothelial cancer treatment after platinum failure. This review examines clinical trials of targeted agents for advanced urothelial carcinoma, offering insights for palliative care options.

Area of Science:

  • Oncology
  • Urothelial Carcinoma Research
  • Clinical Trials

Background:

  • Metastatic urothelial cancer treatment landscape is evolving.
  • Limited options exist in the second-line setting post-platinum therapy.
  • Targeted therapies have shown less efficacy in urothelial cancer compared to other malignancies.

Purpose of the Study:

  • To review clinical studies of targeted agents in second-line treatment for metastatic urothelial carcinoma.
  • To highlight the oncologic outcomes of targeted therapies in this setting.
  • To provide an overview of potential alternative treatment strategies.

Main Methods:

  • Systematic review of clinical trials.
  • Focus on targeted agents investigated in the second-line setting.
  • Analysis of phase II trials for advanced transitional carcinoma of the urothelium.

Main Results:

  • Many targeted drugs investigated as single agents showed unconvincing oncologic outcomes.
  • Vinflunine is a recently approved standard in Europe for second-line treatment.
  • Further well-designed clinical trials may offer alternatives for patients.

Conclusions:

  • Targeted therapy has not yet met expectations in urothelial cancer.
  • The efficacy of single-agent targeted therapies requires further investigation.
  • Clinical trials remain crucial for identifying effective second-line treatments for metastatic urothelial cancer.

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