Related Experiment Video
Updated: May 19, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
Expression pattern of the transforming growth factor β signaling genes in human peripheral blood mononuclear cells
Magdalena Kimsa1, Barbara Strzalka-Mrozik, Malgorzata Kimsa
1Department of Molecular Biology, Medical University of Silesia, Sosnowiec, Poland. magdakimsa@gmail.com
Objective:
The present study has focused on the identification of differences between the expression pattern of TGF-β signaling pathway genes in athletes after exercise.
Materials And Methods:
The study group consisted of three healthy cyclists, which were collected pre-exercise, immediately postexercise, and after 15 min of recovery. The analysis of the expression profile of genes related to the TGF-β signal transduction pathway was performed in peripheral blood mononuclear cells using HG-U133A oligonucleotide microarrays.
Results:
A significant differential gene expression was recorded for RUNX3, TGFBR3, MLC1, and GRB2.
Conclusions:
The effect of physical exercise on immune response may be essential for human health. Moreover, alterations of TGF-β signaling can be involved in the process of adaptation of human organism to physical exertion.
More Related Videos
06:54Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
11:38Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
Published on: September 14, 2021
Related Concept Videos
TGF - β Signaling Pathway
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Regulation of Angiogenesis and Blood Supply