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Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
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Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...

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Updated: May 19, 2026

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
05:37

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Published on: December 22, 2017

Iatrogenic hyperviscosity and thrombosis.

Oguz K Baskurt1, Herbert J Meiselman

  • 1Koc University School of Medicine, Sariyer, Istanbul, Turkey. obaskurt@ku.edu.tr

Seminars in Thrombosis and Hemostasis
|August 24, 2012
PubMed
Summary
This summary is machine-generated.

Hemodynamic factors influence blood flow and thrombosis risk. This review examines how certain drugs, like oral contraceptives and chemotherapy, can increase blood viscosity and thrombotic risk.

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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
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Area of Science:

  • Cardiovascular Science
  • Hematology
  • Pharmacology

Background:

  • Hemodynamic factors, including shear forces, significantly influence hemostatic-thrombotic mechanisms and endothelial cell function.
  • Blood rheology and its components are intricately linked to vascular shear forces and overall blood flow properties.
  • Numerous clinical studies confirm a strong association between altered blood rheological properties and an increased risk for thrombosis.

Purpose of the Study:

  • To review the complex interplay between blood rheology, hemodynamic factors, and thrombotic risk.
  • To focus on drug-induced conditions that elevate hyperviscosity and increase the likelihood of thrombosis.
  • To briefly discuss rheological alterations in artificial circulatory environments and during physical exercise.

Main Methods:

  • Literature review of hemodynamic and rheological concepts.
  • Analysis of drug-induced conditions affecting blood viscosity and thrombotic risk.
  • Discussion of rheological changes in non-physiological conditions.

Main Results:

  • Selected drugs, including oral contraceptives, diuretics, intravenous immunoglobulin, erythropoiesis-stimulating agents, chemotherapy, and radio-contrast media, are associated with hyperviscosity and increased thrombotic risk.
  • Alterations in blood rheology are directly linked to hemodynamic forces and endothelial cell function.
  • Changes in blood rheology can exacerbate thrombosis risk, particularly in stenotic regions.

Conclusions:

  • Understanding the relationship between blood rheology and thrombotic risk is crucial for clinical practice.
  • Certain medications can significantly impact blood viscosity, necessitating careful patient monitoring.
  • Further research into drug-induced rheological changes can inform preventative strategies against thrombosis.