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Updated: May 19, 2026

Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
Spontaneous resolution of macrocytic anemia: old disease revisited
Shinsaku Imashuku1, Naoko Kudo, Shigehiro Kaneda
1Division of Hematology, Takasagoseibu Hospital, Takasago, Japan.
Abstract:
We report here on a 60-year-old male with alcohol-related macrocytic anemia. He was hospitalized on three occasions with hemoglobin < 9.0 g/dL and mean corpuscular volume > 130 fL. Careful history taking and observation of his blood status led us to make a correct diagnosis. At the time of each of his admissions, only with bed rest and abstinence from alcohol did our patient dramatically show spontaneous recovery of anemia in association with a rapid decline of serum γ-glutamyl transpeptidase values. It is well recognized that marrow abnormalities in alcoholic patients are reversible. Physicians should be aware that there is a subset of patients with macrocytic anemia that could be improved without medication.
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