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Updated: May 19, 2026
Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Therapeutic angiogenesis for treating cardiovascular diseases
Lorenzo Deveza1, Jeffrey Choi, Fan Yang
11. School of Medicine, Stanford University, Stanford, CA, 94305, USA;
Insights
Therapeutic angiogenesis uses biomaterials and signals to promote new blood vessel growth, crucial for treating cardiovascular diseases. This approach offers controlled release for enhanced treatment efficacy.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Research
Background:
- Cardiovascular disease (CVD) is a major global health issue, often caused by blocked blood vessels.
- Restoring blood supply is essential for treating CVD.
- Therapeutic angiogenesis, stimulating new blood vessel growth, is a key treatment strategy.
Purpose of the Study:
- To review strategies for therapeutic angiogenesis.
- To explore the use of biological signals, cells, and polymeric biomaterials.
- To discuss advancements in controlled release and cell-based therapies.
Main Methods:
- Review of existing literature on therapeutic angiogenesis strategies.
- Analysis of single and combination approaches using biological signals, cells, and biomaterials.
- Discussion of advancements in polymeric biomaterials for controlled drug delivery.
- Exploration of biomimetic signals and genetically engineered stem cells.
Main Results:
- Polymeric biomaterials offer controlled, three-dimensional drug release depots.
- Biomimetic signals enable responsive or cell-triggered release for targeted angiogenesis.
- Genetically engineered stem cells and cell homing mechanisms show promise.
Conclusions:
- Polymeric biomaterials enhance therapeutic angiogenesis through controlled release.
- Advanced strategies involve biomimetic signals and engineered cells for targeted treatments.
- Future directions focus on optimizing cell-based and biomaterial-based angiogenic therapies.
Abstract:
Cardiovascular disease is the leading cause of death worldwide and is often associated with partial or full occlusion of the blood vessel network in the affected organs. Restoring blood supply is critical for the successful treatment of cardiovascular diseases. Therapeutic angiogenesis provides a valuable tool for treating cardiovascular diseases by stimulating the growth of new blood vessels from pre-existing vessels. In this review, we discuss strategies developed for therapeutic angiogenesis using single or combinations of biological signals, cells and polymeric biomaterials. Compared to direct delivery of growth factors or cells alone, polymeric biomaterials provide a three-dimensional drug-releasing depot that is capable of facilitating temporally and spatially controlled release. Biomimetic signals can also be incorporated into polymeric scaffolds to allow environmentally-responsive or cell-triggered release of biological signals for targeted angiogenesis. Recent progress in exploiting genetically engineered stem cells and endogenous cell homing mechanisms for therapeutic angiogenesis is also discussed.
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