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Updated: May 19, 2026
04:40
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Urinary bisphenol a concentration and angiography-defined coronary artery stenosis
David Melzer1, Phil Gates, Nicholas J Osborne
1Epidemiology and Public Health Group, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom. david.melzer@pms.ac.uk
Plos One
|August 24, 2012
Summary
Higher urinary bisphenol A (uBPA) levels were linked to severe coronary artery disease (CAD). This suggests a potential association between BPA exposure and cardiovascular health, warranting further investigation into dose-response relationships.
Area of Science:
- Environmental Health
- Cardiovascular Disease Research
- Toxicology
Background:
- Bisphenol A (BPA) is a common chemical found in food packaging.
- Existing research suggests a link between elevated urinary BPA (uBPA) and cardiovascular diagnoses.
Purpose of the Study:
- To investigate the association between BPA exposure and the severity of coronary artery disease (CAD).
- To compare uBPA levels in patients with varying degrees of coronary atherosclerosis.
Main Methods:
- The study analyzed 591 participants from the MaGiCAD study in the UK.
- Urinary BPA concentrations were measured and correlated with angiographically determined CAD severity.
- Statistical models adjusted for BMI, social class, and diabetes status.
Main Results:
- Patients with severe CAD exhibited significantly higher median uBPA concentrations compared to those with normal coronary arteries.
- A trend towards higher uBPA was observed in patients with intermediate CAD.
- No significant difference in uBPA was found between patients with severe CAD requiring surgery and other groups combined.
Conclusions:
- Increased BPA exposure is associated with more severe coronary artery stenoses.
- Further research is necessary to establish dose-response relationships and elucidate the underlying mechanisms.
- The findings highlight a potential environmental risk factor for cardiovascular disease.
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