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Updated: May 19, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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Published on: November 5, 2019

[Sickle-cell anemia and pain].

Alice de la Brière1

  • 1Département d'anesthésie-réanimation-douleur, Institut Curie, Paris. alicedesmouliere@hotmail.fr

Soins; La Revue De Reference Infirmiere
|August 25, 2012
PubMed
Summary

Sickle-cell anaemia, a global genetic disorder, causes severe pain crises in 20% of patients. Deformed red blood cells block vessels, leading to organ damage and frequent emergency visits, with morphine as a primary treatment.

Area of Science:

  • Hematology
  • Genetics
  • Vascular Biology

Context:

  • Sickle-cell anaemia is the most prevalent genetic disease globally.
  • Vaso-occlusive crises (VOCs) affect approximately 20% of patients, causing severe morbidity.
  • Red blood cell (RBC) sickling obstructs microvasculature, impairing oxygen delivery to organs.

Purpose:

  • To summarize the pathophysiology and clinical presentation of sickle-cell anaemia.
  • To highlight the significance of vaso-occlusive crises as a primary cause of emergency department visits.
  • To identify morphine as a foundational treatment for pain management.

Summary:

  • Sickle-cell anaemia involves genetic mutations leading to abnormal hemoglobin and misshapen RBCs.
  • These sickled RBCs impede blood flow, causing painful vaso-occlusive crises and potential organ damage.

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  • Emergency care is frequently required for these crises, with morphine being a standard therapeutic agent.

    • Impact:

    • Understanding the disease mechanism is crucial for developing targeted therapies.
    • Effective management of VOCs can reduce hospitalizations and improve patient quality of life.
    • Further research into pain management and disease modification is warranted for sickle-cell anaemia.