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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Related Experiment Video

Updated: May 19, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

[Chronic active Epstein-Barr virus infection].

Hiroshi Kimura1

  • 1Department of Virology, Nagoya University Graduate School of Medicine 65 Turumai-cho, Showa-ku, Nagoya 466-8550, Japan. hkimura@med.nagoya-u.ac.jp

Uirusu
|August 25, 2012
PubMed
Summary
This summary is machine-generated.

Chronic active Epstein-Barr virus (CAEBV) infection, a severe condition in immunocompetent individuals, stems from clonal expansion of infected T or NK cells, not active infection. This review covers CAEBV

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Last Updated: May 19, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Area of Science:

  • Virology
  • Immunology
  • Oncology

Context:

  • Epstein-Barr virus (EBV) establishes lifelong latency.
  • Intact cellular immunity typically prevents symptomatic disease.
  • Chronic active EBV infection (CAEBV) can arise in immunocompetent individuals.

Purpose:

  • To review the current understanding of CAEBV pathogenesis.
  • To summarize clinical features, therapies, and prognosis of CAEBV.

Summary:

  • CAEBV presents with chronic or recurrent infectious mononucleosis-like symptoms.
  • Pathophysiology involves clonal expansion of EBV-infected T or natural killer (NK) cells.
  • This rare but severe disease has high morbidity and mortality.

Impact:

  • Advances understanding of EBV-associated lymphoproliferative disorders.
  • Provides a clinical overview for diagnosis and management of CAEBV.
  • Highlights the shift from infectious etiology to clonal expansion in CAEBV pathogenesis.