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In vitro susceptibilities of Pseudomonas pseudomallei to 27 antimicrobial agents
T Yamamoto1, P Naigowit, S Dejsirilert
1Department of Bacteriology, School of Medicine, Juntendo University, Tokyo, Japan.
Abstract:
Clinical isolates of Pseudomonas pseudomallei isolated in Thailand from 1981 to 1989 were tested for their in vitro susceptibilities to 27 antimicrobial agents, including older and newer quinolones, broad-spectrum cephems, carbapenems, monobactams, penicillins, tetracyclines, chloramphenicol, rifamycin, sulfamethoxazole, trimethoprim, and fosfomycin. Tosufloxacin, meropenem, CS-533, and minocycline were active against P. pseudomallei at levels comparable to or even greater than those of antimicrobial agents tested in previous studies, such as ciprofloxacin, ceftazidime, imipenem, carumonam, and piperacillin. Drug-resistant P. pseudomallei was found in only 1% of the isolates. The drug-resistant P. pseudomallei isolates displayed a unique pattern of susceptibility to the above-listed drugs.
Insights
This study evaluated antimicrobial susceptibility in Pseudomonas pseudomallei clinical isolates from Thailand. Most isolates were susceptible, with few showing drug resistance to tested agents.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Pseudomonas pseudomallei is an important human pathogen.
- Understanding antimicrobial resistance patterns is crucial for effective treatment.
Purpose of the Study:
- To assess the in vitro antimicrobial susceptibility of clinical isolates of Pseudomonas pseudomallei.
- To identify effective antimicrobial agents against P. pseudomallei.
Main Methods:
- Testing of 27 antimicrobial agents against clinical isolates of P. pseudomallei.
- Evaluation of susceptibility to quinolones, carbapenems, cephems, and other drug classes.
Main Results:
- Tosufloxacin, meropenem, CS-533, and minocycline demonstrated high activity against P. pseudomallei.
- Only 1% of isolates exhibited drug resistance.
- Drug-resistant isolates showed unique susceptibility patterns.
Conclusions:
- Several newer antimicrobial agents show significant promise for treating P. pseudomallei infections.
- Low prevalence of antimicrobial resistance suggests continued effectiveness of many agents.